I heard that CAPCOM is saying that they wanted to restart the whole series with new characters and everything. I know how RE5 ends and I think it would be an extremely dry ending to the series if they just ended it like that. If they did end it (which I hope they don't) then they should end it with all the main characters reunited and have some kind of closure for all of them. Like, yay we destroyed the virus and now we can go home.
I know cheesy, whatever. Man, its gonna suck to try and get used to a line up of whole new characters.