The bowgun is SO much fun. I always have around 40 bolts in my case that I keep for random frenzies. I love just grabbing it and doing a few levels with them. I should see I could survive the game with them... Don't know how well that'd work on Krauser, though. lol
Krauser is harder in Seperate Ways. No lie. Less space to fight and more chances to screw up. Krauser really hates her. Saddler's a pain for ammo conservation unless you don't mind getting caught in his lash attack. From there you can stab him. Just make sure you have a few GR herbs. It's quite fun challenging the first playthrough. Not particulaly HARD, but there are the occasional instances where you'll probably die. The Garrador's gotten me a couple of times. First playthrough, he's a bi*** because you're surrounded by Ganados that stun you with arrows.