Looks like I just tied Wesker with Tyrant with my vote, lol!
There have been some good ones no doubt, but I am always a little bit partial to Wesker. He's the ultimate bad guy, then you realize he has crazy, mad powers too. He's a wrecking ball.
Gotta give special props to Bitoris Mendez, a.k.a. Kevin Garnett lol! My son actually mentioned that to me the first time, saying that doesn't Mendez look like the basketball player Kevin Garnett? I think he's a ringer actually. Well, except for that whole not being black, thing. But he's tall, has the nose, the goat-tee. He's dark enough too, lol! Almost looks like they modeled the character off of KG.