For the heroes: Either jill or rebecca. Jill hasnt had her own game since 3 and rebecca hasnt been seen or referred to since zero. Was a very stupid move on capcoms part to leave jill out of RE6, especially after what went down with her in 5. As much as i love them, no chris or leon. People say chris is overused, but leons not far behind. Chris only started appearing everywhere at RE5. Before 5 he'd only been in RE1 and half of code veronica. Leon was in 2,4,6 and two movies that are actually canonical with the games. I just pray to god capcom give attention to their beloved charracters and not create pointless new ones (sheva, helena, jake,piers) funnily enough piers was the only new character in 6 that i could really see having a future in RE and capcom ****ing killed him lol
For the villains: Well there isnt much choice here since umbrellas dead, alberts dead and spencers dead so unless capcom can create a really good new villain withiut turning them into a simmons, its Gotta be alex. I know she 'died' at the end of revelations 2 butvif shes anything like her brother im sure ahe'll be back if capcom need her. Capcom have the potential to make her just as great as albert. Plus they need to explain her connection to natalia at the end of revelations 2.