Can't aim without a mouse, never needed to either, I'm fine with all the other games.
I'm currently in chapter 5-4, stopped right after the Krauser fight, and if there's one thing I love about RE4, it's that it makes me appreciate 5 and 6 even more. Not saying it's a bad game, but the controls are killing me - literally! I have died roughly 40 times by now, not because I'm too blind or stupid to know a threat when I see one, but because I just can't make the Leon tank move quickly enough to evade the occasional lightning-fast one-hit killer, and then there's those totally random QTEs popping up out of nowhere and expecting way too much of an old woman's reflexes.
But apart from that, I noticed for the first time how suspiciously similar RE4 and 5 are, not just because you're basically fighting the same enemies with different names and getting into the same situations all over again, but also story-wise: A boy travels to a remote village to save a girl and stop the bad guy from destroying the world, meanwhile running into a rich male drama queen with an inflated ego who transforms into a huge monster, a shady woman in an inappropriate dress who works for Wesker, and a former friend who was presumed dead, but came back evil and has to be fought. The only difference is that 4 doesn't feel as much like a comic book, which I appreciate.