Are you fogetting our good friend Albert Wesker? He's probably been the most successful BOW
The control aspect was lacking there though. I mean Spencer did put a lot of thought into the Wesker Children Project, but I doubt he was that succesful.
The main things they wanted for their perfect BOW, soldiers.
Intelligence(such as Nemesis being able to handle weapons, same with TALOS)
Power(which I guess would inclulde strenght and all that, something like a Tyrant is something you don't want to mess with)
Control(obviously most BOWs are lacking this one. Tyrants were limited in that aspect, the one from File#2 is a good example, or they would have sort of uncontrollable mutations, etc. Or in Al's case, just have a mind or their own, or just steal Spencer's plans for his own, either way).