Compiled list:
-When you reach the town, at the very beginning of the game, you can either.
A) Sit back and kill the towns people, WITHOUT spawning the first Chainsaw man, OR B) You can go in the house, activate the scene and the chainsaw man and get the shotgun
-When you reach the part with the "Two routes" and you have to pick between the 2 Chainsaw Women, or the El Gigante, Pick the one you feel most comfortable with first, complete the route, then backtrack and take the other route. There are two treasures in these areas.
-In one of the rooms in Salazar's castle (the art gallery), there are four paintings that you have to line up correctly. The easiest way I've found was to put the numbers in this order (4, 3, 2, 1)
-When you first get Ashley back (After sniping the monks out) Don't forget to backtrack and get the Broken Butterfly for free.
-Salazar's Right hand, on professional version, is one of the hardest enemies you'll encounter. Even with the nitrous, Hand cannon, and Rocket Launcher, he still does not go down, so if you want the Treasure he holds (Crown Jewel) you should be prepared.
-take a rocket launcher when you fight the The Right Hand boss get him near a co2 gas tank,freeze him take out the launcher. No matter where you are,shoot him, then he'll blow up into little tiny pieces and die...problem solved (Normal only)
-Fight 2 Salvadors in the Village Fight (And get Double Money)
When you first enter the Village, DONT enter the house with the shotgun. Head to the path towards the farm when you get to the gate, Thereis a Doctor Salvador waiting for you, Kill him and Get the Ruby from him, then enter the House with the Shotgun. Beat this salvador and you get 10000Ptas
-When you and Ashley jump down the garbage disposal shaft (Chapter 5-2), there will be 2 regenerators in the area, the first is right behind you (It'll wake up right after you take a few steps) If your low on ammo from taking the first one out, here is an easy way to not deal with the 2nd one. Put ashley in the metal crate (after pushing the container in the water). When you see the Regenerator coming your way, run back towards the area you first entered in. Back your way up on the pile of garbage and wait for the Regenerator. When he's really close, take one of his legs out with a shotgun (or anything else that will quickly take one out). Run quickly past him and pull the lever on the other side, causing the gate to lock him in. Call Ashley and run through and shut the second gate. Have Ash help you push the crate blocking the door out of the way and make your way through towards the next area.
-Leon: Yeah, I have this thing that keeps following me around...
Ashley: I have a name!
Leon: Yeah, it thinks I listen to it. So I was wondering...
Merchant: I'll buy that at a high price!
Leon: Oh good, I thought I was stuck with it
Ashley:
Merchant: ^^
-Watch out behind you. You never know what can sneak up behind you during the heat of fighting off hordes of enemies. I've found myself facing this problem countless times. To combat this, just make sure to look behind you every so often and listen up for the enemies chatter.
-Upgrade only the weapons you use the most if you have trouble. Upgrading weapons just for the sake of upgrading isn't smart and is a waste. Not to say once you beat the game a few times and you get bored that you can't upgrade everything. Play it smart though, until you have the hang of things.
-I also read earlier about problems facing Verdugo (or Salazar's right hand) on professional. I've actually beat the game on professional on the Gamecube, Playstation 2, and the Wii, so perhaps I could provide a few pointers.
-Run. As soon as you get the chance, run. If you don't have the right equipment, staying to fight this creature is a deathwish. If you want the treasure it holds, it can wait for another playthrough
-If your really running low on ammo on Professional, villagers with pitchforks can easily be taken out with the knife. As they swing it move backward, then run forward and swipe there face, kick them and knife them on the floor. I usually do this mostly without losing health.
-When fightin in the house with Luis against the evil people, stay quite close to him as he gives throws free ammo for you to pick up.
-Whn facin El Gigante, if you have a powerful gun, you can shoot the Plagas on its back rather than climb on him and knife him.
-The biggest way to save ammo is, with the handgun, shoot once right in the face, and then run in for the kick. That gets them on the floor allowing you to pass.
Plus it saves about 5-6 shots trying to kill them.
and if you wanna kill them, after the kick, get knifing.
-When your killing salazar. Its boring but stay in one corner, as far into the corner.
An make sure you keep shooting the tentacle closest to you then this way all you have to do is shoot the eye from the corner (an the tentacle when it pops out so it dont whip you) if you do this nothing can hurt you.Just shoot salazar when he pops out an repeat lol easy as pie, boring as pie to though. Have to be a okay shot to : p like me haha HEADSHOT!
-If your low on ammo shoot the ganandos shins as there running for an escape and even a good laugh.
-Don't upgrade the mine throwers exclusive its stupid because it homes in on the enemy your not trying to shoot.
-In the lava pit in the castle shoot the chains where the stone dragon pits pop up so you can avoid getting grilled.
-If you can't bothered waiting for saddlers eyes to pop up use a the minethrower to drop him instantly.Proceed with a magnum.
-When you get to place in the village where you soon meet the first giant and the dog who comes to save (you get locked in)there are loads of crows. Use a Flash Grenade on them and they will give you grenades, money and a spinel.
-Shoot all crows (one shot needed) for rewards.
Oh and dont forget to shoot birdsnests for ammo and small bits of treasure(especially around the lake and graveyard).
-When you go into the mezzanine hall in the castle ( where there are like 50 monks.) Equip a grenade and sprint up to hit the line in the middle of the room, thenconstantly move around while uloading with the TMP. Worked really well for me.
-Shoot the attacker in the leg, brings them down half way that way you can run up and do leons special move. Which if they have a few more behind then, it will knock them back aswel, giving you the chance for a few headshots. If you do this in the Village, you'll just Kick them, but if you do it in the Castle and the Island, you'll Suplex them.
-When Ada throws you the Special Rocket Laucher do not use it. You can sell it for 30000 ptas on your next round so just kill him naturally.
-In the rooms with falling SPiked ceilings, don't run hastly into that room. Wait at the door opening (make sure you still don't go into the room!) and aim with your handgun to the ceiling. If it's right, there would be four lighting red lights out there. Shoot them all, go into the room, watch the cutscene calmly, laugh at Salazar's early celebration and play on =) Those spikes won't do anything to you.
-Right after your first encounter with a Ganado, you will have to walk down a long path and fight a more. As a beginner, i felt annoyed having to conserve my ammo. Or maybe it's just me.. anyway, remember those annoying exploding cords? Well to conserve ammo i lured a bunch of guys into them. In the trail there are two, but i was satisfied. Just watch out for bear traps!
-In the very beginning you will see a dog caught in a bear trap. Walk up to it and save it and you will be rewarded! Later in the game you face the El Gigante. He will help distract the massive creature and you will love him for it.
-As you enter the farm to the right of the little hut with the barrel and type-writer, you will see an amulet/necklace hanging. If you just shoot it and take it, it will be dirty and go for 3,000. But if you shoot the stick holding open the panel, it will drop and cover the water, thus making it clean if you shoot the necklace. Shoot it, take it, and it will go for either 5,000 or 10,000.
-Kauser can be a pain, but he takes a lot of damage from a knife. Get your knife ready and let him attack you. Just as he begins to attack, slash him and he'll drop to one knee. Then he'll get up and backflip. If you have him cornered he'll backflip against a wall and you can run over and knife him again, but if not then I dont recomend knifing him after backflipping.
-At the very beginning of the game, The Merchant offers you a Punisher for 10-15 Blue Medallions. Even if you hate the Punisher, do it anyway and sell it immediatly afterwards for extra cash. The ammo you use to shoot the Medallions if deffiantly worth it.
-If you see a bin or dumpster to put Ashley in, do it. Clear the area of enemies, then call her over.
-Bear Traps dont have to be shot at, just get up close and use the knife.
-Ganado are immune to bear traps, so dont even try. Trip Wire bombs however, are great ways of killing Ganado. Just walk around it and watch them detonate them.
-For the Del Lago fight, keep your health up. The lower your health is, the slower Leon will swim if he gets knocked out of the boat, so always keep your health green.
-In the room in Salazar'd dungeon with the two El Gigantes. Killing both naturally earns you both of their treasure, but if you use the lava pit on one, fight the other, leave the room and come back, the treasure from the lava pitted one will appear.
-Also, in the fight with the first El Gigante, if you manage to get him on one side of the fire places, and yourself on the other, the onyl attack he can do is his double fist slam. When he does that his fists will go through the fire. Knife his fists and rinse, lather, and repeat.
-For the second El Gigante battle in the double paths. Use the boulder to distract him as you and Ashley escape. Or, fight him. If it grabs Ashely, just keep shooting his arms, and he;ll drep her.
-In the dual El Gigante battle, drop one in lava, then lure the other one to the structure. Climb to the top and manually turn around (not auto turn) and immediatly jump down. He'll start to shake the structure and knife him while he's doing his shaking animation. Get in 4-5 good knifes, then climb up, manually turn around again, and repeat. Its time consuming, but you beat it using no Health items and using no ammo.
-This hasn't been said, but stupidly, Flash Grenades kill Plagas instantly. Just to tell ya, but you all already know.
-In the Krauer battle, just before the tower, dont run past the robots. If you're low on ammo, these guys drop a ton, and take just one shot to kill and often take others down with it.
-While Mike is with you on the island, if you're having a tough time with turrets or barriers, just back off and let Mike destroy them first.
-Regenorators can be skipped easily. Just walk forwards, and they'll rush forwards to grab you. Just step back, and they'll fumble. At this point, run past them. This is a great way to avoid Regenorators if you forgot or sold the Thermal Scope.
-After meeting with Ada (the part where she stabs you) there is a long corridor with a Regenorator. After you kill it, the Thermal Scope is useless. Sell it for extra money.
Glad I could help. If someone (Thread originator or a mod) could put this list in the first post that would be mega helpful to everybody. Going through every page of this thread was a tad boring for tips!