Just the once. Halfway through my second play through with the PS3 HD version now, although this has taken me a while (I got it when it came out). If you can't tell, barring RE6, RE4 is probably my least favourite main RE game.
One of my files went to 20+ plays, but now I tend to only do new game runs which take longer. I'd estimate maybe 40-50+ run throughs. A whole bunch back on GC, more on the emulator on my computer now.
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