In any case, it will see ligth no sooner than fall 2012...
This adds to the idea that it can't be Leon... He will be the protagonist of his own CGI movie then...
Claire is not much of a choice, they explain in the first CGI movie (the one in the airport, can't remember the name) that she has moved to the "desk job" side of counter-bioterrorism...
Billy Coen is "dead"...
Rebecca, probably...
Barry, too old...
Carlos, we haven't heard of him since RE3, and I have the feeling we won't see him again...
Ada, please
; but unlikely, she is bound to appear in Leon-games...
Jill and Chris, Revelations...
Wesker, DEAD (accept it!)
A platypus, it woud be too much...