I know he isnt, but the virus is the same to him as it is with them in a lot of ways...and i'm not saying he is invincable...i'm saying he dosnt feel pain...i'm saying that the reason you plug him with 500 bullets is because he can't feel the pain and know to retreat...he just passes out due to the damage his body took...i never ONCE said he was invincable...quite the contrary actually....
Well I'd like to add my two cents, though it seems like you guys have already pretty much covered it all.
But yes, Tyrants are not invincible, though I don't imagine they can feel pain. That said, if a person is on PCP and you tazer them, they'll still come at you, but can still be killed.
Oh, and of course the way something happens in the games, as far as gameplay is concerned isn't....real, or canon I guess. i.e. when you get bit by a zombie in the game, you just lose health.
Same applies to fighting enemies. I assume that if you were to shoot in the brain, right between the eyes, or certainly blow off a Tyrant's head, they would die.
I mean, in Degeneration, when Leon shoots Curtis in the head, he fell down, maybe not toally dead, as G probably would have revived him, but still, effective.
But yeah, I like to think that if in real life, you were to shoot them in the head just right, they would die.