Story 1:
Chris Redfield learns that his sister Claire has been captured in retaliation to BSAAs actions and that she's been taken to a research facility. Unsure whether it's a just small leftover band of thugs, a surviving bioterrorism cell or a potential successor cult, Chris decides to assemble a strike team: Jill Valentine joins without hesitation, Barry Burton and Rebecca Chambers appear surprisingly wanting to help Chris. In addition a dozen BSAA troopers join the squad. Leon Kennedy has also heard about Claire's disappearance and demands to get on board.
The team heads off to the research complex in a couple of choppers. Facing some light J'avo resistance, the team manages to infiltrate the building. Dividing into smaller units they delve deeper into the suspiciously quiet and omnious complex. Suddenly doors seal up, elevators go crazy, trapdoors collapse and a group of monsters arrive. Half of the strike team is eliminated and the other half are seperated from each other. Claire hears the loud action and under chaos she manages to break out from her cell, starting to sneak around and trying to figure what's going on.
Chris, Jill, Barry, Rebecca, Leon and a couple of soldiers are still alive, seperated. There is some static, but their radios work alright, most of the time. The members of the squad are exploring around, facing lots of locked doors and an occassional panicking Majini or Ganados guard. As the team pokes around learning that the facility is related to Umbrella, zombies start to roam the corridors......... Rebecca finds a control panel that opens a door for Chris.......... Barry meets Jill and they team up for a moment, but soon a soldier is calling for help and Jill goes to help leaving Barry behind.......... Claire finds a keycard............ Leon solves a computer puzzle............... As the team discovers more and opens up more passages, more dangers appear. They find out that the place is used to contain and experiment on all the past and potential future viruses. Everything starting from dogs to spiders to lickers to regenerators to garradors to reapers to rasklapanjes to plants are contained within the facility, along with new experiments. Quickly the condition of complex goes from bad to worse. Explosions, fires, floods, ripped walls, collapsed roofs, broken elevators, leaking chemicals, exposed electricity, blinking or broken lights all take toll and make things tougher. Fortunately some of the monsters don't like each other either and environment is hazarous to many of them too.
Team keeps exploring and unlocking new paths........... Leon finds an empty cell in the containment area and encounters an Uroboros Mkono...... Rebecca finds samples of viruses in the laboratories and sees Del Lago in an aquarium...... Jill explores the housing block and faces an Executioner...... Chris is trying to get some power back on in generator room....... Barry gets in trouble in testing grounds.............. The team knows they need to look around for Claire, and they're setting up explosives in case they need to blow the place up............ They discover that even high class creatures such as Tyrant, Giant Moth, Nemesis, El Gigante, U8 and Ustanak are located in the facility....... Each hero bumps into one of the monsters and either take them down, escape or lure the monster into trap or to fight another monster.
Leon and Claire finally meet up. As they're exchanging words Steve Burnside is looming over them. He approaches and Claire notices him. The three talk and soon Steve is swinging his tentacle hand at them, pushing Leon and Claire down. As Steve gets ready to finish Leon off, Chris steps in front and fights Steve. Steve gains the upper hand and talks about how he's waited for this chance to pay back for Albert. He fatally wounds Chris right before Jill, Barry and Rebecca manage to interfere. Claire stays with Chris and they exchange final words while the other 4 chase Steve. They take him down and he falls into the ocean. The team returns to Chris. Nothing could be done and they hurry away using only one of the two choppers to escape. The facility is blown up.
Later Steve is shown to revive in the water.
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Story 2:
The more modest mercenary Jake Muller is eliminating B.O.Ws in Middle-East. Ada Wong is observing him and after a while confronts him. They talk and Ada explains she can help him understand his past. Jake isn't in a hurry and wants to eliminate the B.O.W threat first and help repair his father's errors. Ada doesn't let go so easily and assists him. The two move through towns and deserts fighting B.O.Ws. Both being mysterious figures, they are curious about each other.
As things get more and more awry and weary, Jake is questioning whether they can do this after all. He wonders if the status of Earth will just get worse and worse no matter how much they fight. The thought of using a virus pops up. Ada offers a vial convincing that it won't do anything to his mind and that Jake is the best chance against bioterrorism threat there is. Jake relucantly agrees, swearing he won't become like his father. Stronger, they continue their journey and destroy the B.O.W threat in the region. Even in their moment of victory, Jake witnesses the destruction and death with a suspicion that B.O.W threat still isn't over, if it will ever be. Ada reminds Jake of her request and Jake agrees to come along. They head towards a research facility.
Ada and Jake arrive at the complex and proceed to a room. Suddenly a voice in the speakers thanks Ada stating that her payment will be delivered shortly. Jake is asking what the hell is going on and Ada answers she had to get something for her work too. Meanwhile a monitor shows Leon talking with Claire and getting hit before Chris steps in. Both Ada and Jake are looking at the screen in awe, Ada calling "Leon" and Jake calling "Chris".......... During the confusion Jake blames Ada for cheating him and Ada says she's just completing an assignment and has no idea what's going on. The two start to argue and fight. Ada is forced to kill Jake. As Ada sighs and looks at the monitor ready to go help Leon again, Jake is getting up. Before Ada can do anything, Jake shows off his Progenitor-virus powers until he finally kills Ada. A voice congratulates him and welcomes Wesker back. The voice introduces itself as Steve who has now returned the favor.
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Story 3:
A person is at his home sleeping as a couple of choppers fly over the town. A few hours later he wakes up in noises and screams. The person gets up and through the window sees something is wrong. The person goes out to the door and sees eerie destruction: a couple of small fires and corpses along with a swarm of undead. Disbeliefed but remembering the rumors about annihilation of Raccoon City, the person knows that escape is the only option. After a nightmarish night of evading zombies and other dangers on the streets, in the buildings, in the sewers and in the nearby forest, the person is picked up by a lone chopper from a rooftop.