I never thought about Chris injecting himself with the virus, that would've been BRILLIANT! He pushes Piers into the escape pod and tells him to carry on his work, and watches as he shoots off.about Helena ending it feels like Leon has passed the torch to her, although it still too early to say she 'll become female version of Leon (dunno why they gave her slutty RPD cop customs in merc).
Chris ending, it should Chris who injected himself with C-Virus & sacrifice himself for Piers, that's will be epic & memorable. I don't know how long Capcom will using Chris as hero, but he is really need retired, and I've got impression Chris will be always alone, not marriage because he thinks, it's not safe to have family (children & wife) while B.O.W still running in the earth.
Jake & Sherry have already done good job as future hero & heroine of Resident Evil.
I would've cried like a little girl if that happened.