This is relative. If there is really a restructuring of every game scenario, there would be no problem. The atmofesra of the mansion should continue.
However, the game could start in the middle of the Raccoon's Forest. After a few minutes gameplay, the Alpha Team would find the mansion. The interior of the mansion should maintain the original architecture, but much wider and with new compartments. The cemetery and the hut area would have to be enlarged.
Also, the pool area and the doctors' rooms could be amplied. Finally, The Spencer's Mansion could win a winter resort look in poll area, as is original propose. Wide and extensive. More rooms, more rooms, more trails.
The laboratory, anyway, could use that conceptual art RAccoon City D, from RE2make. A cable car accessing a factory in the middle of the woods. This factory can be a factory of remedies, real remedies manufactured by Umbrella. The occult lab could have a coherent and consistent structure, not the surreal and untrue structure of the two original games.