I completed the game using Jill with the Original control style, or Tank controls as they are called >_> I found it enjoyable, played it through on normal mode without any issues it was fun.
However I just tried playing as Chris, and I switched to the Alternative control style and wow. Yes that will take some getting use to and as mentioned above when you use the Alternate control style and the camera angle changes, it makes your next turning a little off, hard to explain but it makes you judder in place, but I still need to get use to it..
I'm going to say I don't like the Alternative controls because, & to answer the threads question. No, it does not make things harder. Id say it actually makes things easier, because you can dodge zombies and turn back on yourself a lot faster, resulting in you being able to run away from almost any situation... Almost... didn't stop me from getting slaughtered by the Crimson head outside the Armour key room but it does feel like it's a bit... a bit of a handicap to makes things easier.
EDIT.
In addition to all that.
One thing I realised about the Alternate Control scheme is that it abandoned the pushing up on the analog stick moves your player directly forward (the direction there facing), instead it moves the character in the direction you move the stick in. This kinda effects the classic feel of the game, You should all know what I mean by that.
However the Alternate Controls do give you the power to turn full circle. I'd like to see a Alternate Control scheme that still uses the Pressing Up moves your character directly forward in the direction your facing, but allows you to run and turn full circle and gives you enhanced turning.. (this is getting confusing really fast, if you've tried out the control schemes you should know what I'm ranting about).