The OG is the best. The Director's Cut as far as i remember just has like different BGM throughout like for MF1, MF2, the gaurdhouse, etc. Minor things. I really enjoyed REDS(Deadly Silence). It plays just like the OG 'cept it has some upgrades with the controls, like you can manually reload(like in RE4) instead of having to deplete your ammo or having to go into the inventory. It also has the 180° turn, and it implemented the quick knife like RE4 instead of having to use up a space in your limited inventory and equip it.
That's about all i can think of. Maybe enemies might've had different placement.