According to http://residentevil.wikia.com/Mr_X and http://residentevilfan.com/encyclopedia/details.asp?id=305 he was instructed to go after Sherry because she carried the last known to be intact G-virus sample after HUNK's mission was botched.
OK so this has been on my mind for like 8 years... IF RE2 is ever remade, I think CAPCOM should include a fight between Mr. X and an early mutated stage of William Birkin, since MR. X is after Sherry for her G-virus sample and since William is after her for her use as a host for his embryo...
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