He said cloning is not a part of the Resident Evil universe? What about the 10 clones of Sergei made for tyrant development?
I don't think Chris should die just because Wesker isn't in the series anymore. I actually think he had the best story in RE6, which shows he doesn't need Wesker or Jill to justify his appearences. Besides that, there's still the Alex Wesker issue, which might become a Chris/Jill game. Even if he is to be taken out of the spotlight, he can continue fighting even if he isn't in the main games, no need to kill him.
I wonder if Chris ever knew he was chasing a fake Ada. If not, he might be in another game chasing Ada (thinking she's the Neo-Umbrella Ada).
There's also Jessica Sherawat and Raymond Vester, Chris and Jill may want to find out what they're up to.