I’ve bought pretty much everything other than the infinite weapons now. I’m planning on going through Nightmare and Inferno without them, then get them afterwards to do S runs on those modes.
I manage to do nightmare whitout any special item, can be done easy, only nemesis final boss is really hard
I get 2 hour and 46 by searching everything, so i think it's pretty plausible to make the s rank whitout special item, I'm currently on inferno, it's harder since there are no auto save, but i manage to get to the sewer whitout much trouble, the s rank on inferno could really be a pain
I hope you manage to get it
Good luck
@UniqTeas if you use the infinite rocket launcher on inferno every enemy will die whit one hit except nemesis first form that takes two hit, and nemesis second form who take some hit, but since you can fire in successione it would make it easy, it's easyer than easy mode, you can finish the game in less than an hour getting s rank