It's totally speculation but.... at E3 Capcom had a game that was a demo for the press called "Project Kitchen". There is something very eerily familiar about the game..... It's just something that.... really made me think of scenes from Revelations 2, and I just couldn't help to ignore it.
That being said unless it's a spin off or going to be vastly different like RE4 was then I don't see it. Resident Evil has become very story based and very convoluted in many peoples opinions. To be honest it's also another reason why it's one of my all time favorite series. So I don't see how they can do this... however I DO believe that RE7 is going to be so vastly different that many fans will not recognise it at first. Hell... I'm even willing to bet on it