My heart says Chris for the same reason Magnolia stated, plus his story is getting repetitive. Seriously, how often will we still have to watch him try to cope with a recent personal loss? He's getting quite old as well, by Capcom's standards at least.
My brain says Claire because out of all characters listed in the poll, she's most unlikely to ever be caught in an outbreak again. Of course, there's that old running gag about Claire coincidentally getting involved in an outbreak wherever she goes, and it worked for RE2, Code Veronica and Degeneration, but yet another time would be unrealistic. (Although repeating stories seem to run in the Redfield family, huh?)
My creativity says Leon because he's the character I can relate to the least, meaning that if I was a Resident Evil story writer at Capcom, I wouldn't know what to do with him. His personality has been inconsistent throughout the games and movies ever since his first appearance, which makes character development difficult, and the LeonXAda telenovela, the only thing that never changed (but should have), is getting old.
I couldn't really decide, so I voted Jill simply because I find her the least interesting. There would be much potential to evolve her character now after that whole Wesker ordeal, but I don't think Capcom can pull it through or that her fans would even like it. But newer characters such as Sherry, Jake, Piers and even Helena (although she can be seriously annoying at times) seem to be more elaborate anyway, so why not just drop everyone and let some newcomers take over? The only one I'd really want to keep is Ada, at least until we know everything about her.