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That sounds like a pretty weird glitch! Which graphics card are you using and are you updated to the latest official drivers? I know that Nvidia rolled out some brand spanking new drivers a day or two before Resident Evil 7's official launch, but not sure where AMD stand driver-wise.
Also, have you tried running Resident Evil 7 in Windowed or Borderless Windowed mode?
Not to my knowledge, but my thinking is that perhaps the game, with its many faults on PC, is trying to full screen across both monitors, failing to do so, then perhaps putting the second monitor into standby mode. When I've had a HDTV in the past as a second monitor, it would be triggered into standby mode by the craziest things, even by alt+tabbing. I currently have a projector as my second 'screen' and it does not like displaying different content to monitor #1. When the screens are duplicated it's all fine and dandy.Does windowed mode cause a performance hit?