[Chris] lost his lover for a moment of time, [...]
Only for a moment of time? I thought Wesker was supposed to
stay dead this time.
Anyway, I don't think Chris will attempt to end Jake's life just for being Wesker's son. We all know that Chris is not the most intelligent character Capcom has ever thought up, but he does have a sense of justice, and wouldn't kill a person just because one of their parents was an asshole. And Chris being killed by Leon and Sherry, that would be like Lara Croft drowning in her bathtub.
However, as much as I love him, I think he should retire. As svp said, his whole life must have been one nightmare after another for the last fifteen years, he has earned himself some peace already. And to be honest, I think that's just what's going to happen. It may not be a coincidence that so many people find themselves reminded of a younger Chris when they look at Piers. Perhaps he will become the new Chris now, along with Jake, Helena and Sherry as the new Leon, Jill and Claire?
And yes, I also think we've seen enough of Jill and Leon by now. Not because I don't like them, but for the same reason as in Chris's case. Claire should appear in another game, we haven't seen her for years, but everyone else may as well leave the stage now.