You've been warned, I just got this from here, the same guy who's been posting the spoilers for quite some time now. http://www.gamefaqs.com/boards/605603-resident-evil-6/63312495
It's still unclear, but it seems pretty obvious who Leon's final boss will be... Scroll down for details:
"Jake's final boss is Simmons, which is the man Helena accuses of being behind the current outbreak and we see talking with Ada. Sort of predictable he'd be one of the final bosses, but it makes sense for a 'hero's tale' like Jake's for the main villain to be a boss, especially since Simmons seems to be Sherry's boss and the one asking for Jake. Simmons seems to have mutated for this battle, as there's mentions of him having a tail, a shell on his back, and some form of a lance. The boss seem to have three phases, with attacks using it's lance, using it's tail, some biting attacks, dashing tackles, and more. One phase seems to have Simmons lances be deflected back at him by Jake. Another phase seems to involve Simmons flying. The final phase seems to be Jake tapping into his inner Wesker and running for the last strike.
Chris and Piers also have a final boss against.... Something. To be honest, I have no idea what the heck it is but it sounds like it's linked to those cocoon enemies we see some in the story and E3 trailer. It seems it might be a 'mother' J'Avo, as it is able to give birth to Sanagi (which is Japanese for "chrysalis", or "pupa", and seem to be 'born' but can be killed before their 'birth' happens. The boss can do things like make the enemies around it stronger, has some sort of drain attack, some nail or 'needle' attack, and has 'plates' and 'sections' to its body. Sounds like a real monster, and possibly a queen J'Avo or something. Like how it's appropriate for Jake and Sherry to fight Simmons as their story is more of a 'Hero's story' and it makes sense to have a 'bad guy', Chris's story, which is a tale of Chris really trying to find himself again and live up to his mistakes, makes sense to end on a 'monster' that is directly at the heart of this. A BOW, which he is seeking to destroy and eradicate from the world.
It's not quite clear what Leon's story final boss is, but based on files it seems that either Leon's or Ada's final boss fight may include Leon and Ada either working together or against each other. Leon and Ada are both in the fight, and it looks like they either are partners or are against each other. Either outcome, it either seems that something happened to Helena, or Leon and Ada have a final confrontation. Leon's end boss is kinda' mysterious at the moment, as it's not clear if this Leon x Ada stuff is at the end of Leon's or Ada's campaign, it's not clear if they're working together or against each other, and there's also some clues that an enemy titled in the files as 'CHASER' is involved, but the Chaser may be Ustanak. Guess we'll have to wait and see."
It's still unclear, but it seems pretty obvious who Leon's final boss will be... Scroll down for details:
"Jake's final boss is Simmons, which is the man Helena accuses of being behind the current outbreak and we see talking with Ada. Sort of predictable he'd be one of the final bosses, but it makes sense for a 'hero's tale' like Jake's for the main villain to be a boss, especially since Simmons seems to be Sherry's boss and the one asking for Jake. Simmons seems to have mutated for this battle, as there's mentions of him having a tail, a shell on his back, and some form of a lance. The boss seem to have three phases, with attacks using it's lance, using it's tail, some biting attacks, dashing tackles, and more. One phase seems to have Simmons lances be deflected back at him by Jake. Another phase seems to involve Simmons flying. The final phase seems to be Jake tapping into his inner Wesker and running for the last strike.
Chris and Piers also have a final boss against.... Something. To be honest, I have no idea what the heck it is but it sounds like it's linked to those cocoon enemies we see some in the story and E3 trailer. It seems it might be a 'mother' J'Avo, as it is able to give birth to Sanagi (which is Japanese for "chrysalis", or "pupa", and seem to be 'born' but can be killed before their 'birth' happens. The boss can do things like make the enemies around it stronger, has some sort of drain attack, some nail or 'needle' attack, and has 'plates' and 'sections' to its body. Sounds like a real monster, and possibly a queen J'Avo or something. Like how it's appropriate for Jake and Sherry to fight Simmons as their story is more of a 'Hero's story' and it makes sense to have a 'bad guy', Chris's story, which is a tale of Chris really trying to find himself again and live up to his mistakes, makes sense to end on a 'monster' that is directly at the heart of this. A BOW, which he is seeking to destroy and eradicate from the world.
It's not quite clear what Leon's story final boss is, but based on files it seems that either Leon's or Ada's final boss fight may include Leon and Ada either working together or against each other. Leon and Ada are both in the fight, and it looks like they either are partners or are against each other. Either outcome, it either seems that something happened to Helena, or Leon and Ada have a final confrontation. Leon's end boss is kinda' mysterious at the moment, as it's not clear if this Leon x Ada stuff is at the end of Leon's or Ada's campaign, it's not clear if they're working together or against each other, and there's also some clues that an enemy titled in the files as 'CHASER' is involved, but the Chaser may be Ustanak. Guess we'll have to wait and see."