It was made to be a "what-if" scenario. None of the characters from 2 and 3 ever met any of the new characters in this game during that timeline. The color of the virus is different, too. The game is more like a mixture between the games and the live-action movies, not canon to either but has elements from both.
With ORC though, Nemesis has the design that his counterpart in the movie did, not 3 or Umbrella Chronicles, and the T-Virus is blue like it was in the movies, as opposed to the green in the games.
That, and the fact that you can kill off the main characters of the core series. Unless, you know, you stop playing halfway through because the game bores you to tears. Or the crappy cover system f**** you over and gets you killed one too many times and you launch your controller. Or the fact that the game was such a wasted opportunity that you eat the disc out of frustration.
True, but in the context of the whole games premise, your the bad guys, so why wouldn't you?
It's just a shame that Slant 6 screwed the pooch with ORC, because it does have some glimmers of potential in amongst the murk (almost all of which stem from the core idea of working for Umbrella), but they all got buried under a ton of terrible development choices.
The game isn't Canon Capcom itself say it... Also it contradict the event from resident evil 2 and 3... There is a mission in Whic you must pursue leon soon after he had the car accident whit claire, this alone make this game non Canon since leon was never followed by any soldier from the uss after the car accident in re 2, he just went to the station...
Probably just the first two level could be semi Canon but the rest Is completely non Canon...