I did both of them, but first I did the sisters, then El Gigante. I did both of them in one run. Before I would go through the whole map of the chainsaw sisters(after beating them), I went back and did El Gigante. It was on normal difficulty and right now I am trying to beat it on professional( I don't think its going to work this time).In Resident Evil 4, do you prefer going Left or Right? Chainsaw Sisters or El Gigante?
I didn't know you could skip one of them - I did both but they were equally difficult in my opinion. Then again I'm a sucker for collecting stuff so it's no surprise that I wanted to make sure that I had explored every area available.